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Research Findings

  1. Development of a seaweed NutraDrink: Based on a novel solvent free extraction of sulphated polysaccharide and phenolics from seaweed, a nutraceutical drink (NutraDrink) wasdeveloped. A macroporous adsorbent resin was used to selectively remove the compounds responsible for seaweed off-smell. 
  2. Iron-Calcium-Fortified-Fish Soup Powder (FSP) was developed with the objective of addressing micronutrient malnutrition with special reference to improving iron levels in vulnerable population. Intervention among adolescent girls of West Jaintia Hills District, Meghalaya using fortified FSP showed promising trends in blood hemoglobin levels.
  3. Microencapsulation of thiamine and pyridoxine Vitamin B1 and Vitamin B6 were encapsulated with vanillic acid grafted chitosan and subsequently spray dried. The wall material was synthesized following optimized protocol, starting with 20 g of chitosan and 20 g of vanillic acid to obtain  microparticles of encapsulated thiamine and pyridoxine.Dietary supplementation of Thiamine -pyridoxine-vanillic acid-grafted chitosan is an effective means to prevent cardiovascular disease. 
  4. Fish oil rich in PUFA supplementation effects the mRNA and protein expression of  enzymes of lipid metabolism. Fish consumption has been associated with several health benefits as demonstrated by epidemiological studies worldwide.  The positive effects are thought to be due to the predominance of n-3 PUFA in fish. To elucidate the possible mechanisms of action, we used RNA expression studies for determining the level of expression of four genes in liver of wistar strain rats namely acetyl co a carboxylase (ACC), fatty acid synthase (FAS) and steroyl Co A desaturase-1 (SCD-1) in response to feeding fish oil. Using western blotting technique the levels of ACC, FAS and SCD-1 enzymes expressed in the liver were determined. 
  5. Development of a co-delivery system of Betalain and PUFA: Multiple emulsification and microencapsulation followed by spray drying was adopted to prepare stable PUFA. Microencapsulation is one of the promising methods that can minimize oxidative deterioration of ω-3 oils by converting into a stable free-flowing powder.
  6. A stable fish oil powder was developed using emulsion and encapsulation technology. Cardioprotective effect of encapsulated fish oil powder was  established in cardiomyoblast cell lines.
  7. Wall material optimization for squalene encapsulation led to the development of stable emulsion of chitosan (CS) and whey protein isolate as the emulsifier.  
    Cakes fortified with squalene microencapsulated with chitosan-whey protein complex had superior oxidative stability and textural quality.
    Microencapsulation of squalene with maltodextrin and whey protein isolate gave an encapsulation efficiency of 96% and oxidative stability of more than four months. 
  8. Supercritical fluid extraction of Fucoxanthin and lipid from brown seaweed Sargassum sp. Fucoxanthin content in the extract was determined by HPLC and found to be 1.5 mg/g of the extract. The extract was also found to be rich in different saturated and unsaturated fatty acids. Since fucoxanthin and seaweed lipids are known to possess bioactivities, the extract could potentially be used as nutraceutical supplement. 
  9. Dietary fibre from G.edulis, S.wightii and U.lactuca extracted unde roptimized conditions were analysed for their physicochemical and functional properties likeFT- IR analysis, hydration properties (water holding capacity and swelling capacity), oil holding capacity and antioxidant properties (total phenolic content, DPPH free radical scavenging activity and reducing power  assay).
  10. Acetone and chloroform extracts of Ulva  lactuca showed antibacterial activity towards Salmonella typhimurium, Morganella morganii, E.coli, Listeria monocytogenes and Staphylococcus aureus.
  11. Nine tropical potentially edible seaweeds from Phaeophyta and Chlorophyta were studied for their nutritional composition, mineral content and nutraceutical potential. The seaweeds considered for the studies were green (Ulva reticulata, Valoniopsis sp., Boodlea composita, Caulerapa sertularioides) and brown (Sargassum johnstonii, Padina gymnospora, Padina tetrastromatica, Cystoseira indica, Dictyopteris australis).
  12. Extracted, purified and characterized proteoglycans from E. brucus. Cytotoxic effect of proteoglycans from E. brucus against He La (Breast cancer) cell lines was elucidated.
  13. Anti-inflammatory and anti-ulcerogenic activity of Bramble shark liver oil and sardine oil was demonstrated in wistar strain albino rats.
  14. Myctophid biochemical database was developed. Biochemical and nutritional evaluation of mycotphid fishes was carried out. Fatty acid profiles of Myctophid fishes were profiled and compared
    Fatty acid profile of Myctophid fishes were compared with common food fishes. Myctophid fishes were found to be rich in omega-3 Polyunsaturated Fatty Acid such as DHA. Myctophid fishes were solar dried and dried fishes were subjected to Supercritical Fluid Extraction for fatty acid extraction.
  15. High pure acid soluble collagen (ASC) with potential anti-ulcer property has been extracted and purified from the airbladder of the fish Pangasiushypophthalmus. The purified collagen was found to belong to type I collagen, comprising of two different α chains (α1 and α2).
  16. Anthocyanin loaded chitosan nanoparticles with potent antioxidant activity were developed by ionic gelation method for nutraceutical applications.

 

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